Increased sensitivity of p53-deficient cells to anticancer agents due to loss of Pms2
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چکیده
منابع مشابه
Apoptosis, p53, and tumor cell sensitivity to anticancer agents.
A widely held tenet of present day oncology is that tumor cells treated with anticancer agents die from apoptosis, and that cells resistant to apoptosis are resistant to cancer treatment. We suggest, in this review, that this tenet may need to be reexamined for human tumors of nonhematological origin, for two principal reasons: (a) cell killing has often been assessed in short term assays that ...
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15 صفحه اولMetallothionein null cells have increased sensitivity to anticancer drugs.
Overexpression of metallothioneins (MTs) protects some cells against heavy metals, mutagens, anticancer agents, and reactive oxygen species. We have examined the effect of the loss of MT expression on the cytotoxicity of anticancer agents and mutagens using embryonic fibroblast cells from transgenic mice with targeted disruptions of MT I and II genes (MT -/-). MT -/- cells expressed no detectab...
متن کاملMetallothionein Null Cells Have Increased Sensitivity to Anticancer Drugs1
Overexpression of metallothioneins (MTs) protects some cells against heavy metals, mutagens, anticancer agents, and reactive oxygen species. We have examined the effect of the loss of Ml expression on the cytotoxicity of anticancer agents and mutagens using embryonic fibroblast cells from transgenic mice with targeted disruptions of A/7 / and // genes (MT —/—). MT —/— cells expressed no...
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Background and Objective: Carvedilol, a non-specific β-blocker, has been used for treatment of hypertension, stroke and congestive heart failure. The therapeutic effects of β blockers in cancer patients have been shown. Carvedilol has considerable anti-inflammatory, anti-tumor and anti-angiogenic properties. In this study, the effects of carvedilol on proliferation of human U937 and Molt-4 leuk...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2002
ISSN: 0007-0920,1532-1827
DOI: 10.1038/sj.bjc.6600599